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Article

Sites of volatile anesthetic action on kainate (Glutamate receptor 6) receptors.

The Journal of biological chemistry - 3 Apr 1998

Minami K, Wick M J, Stern-Bach Y, Dildy-Mayfield J E, Brozowski S J, Gonzales E L, Trudell J R, Harris R A

Abstract excerpt

Molecular mechanisms of anesthetic action on neurotransmitter receptors are poorly understood. The major excitatory neurotransmitter in the central nervous system is glutamate, and recent studies found that volatile anesthetics inhibit the function of the alpha-amino-3-hydroxyisoxazolepropionic acid subtype of glutamate receptors (e.g. glutamate receptor 3 (GluR3)), but enhance kainate (GluR6) receptor function....

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Identifiers

PMID: 9525931
DOI: 10.1074/jbc.273.14.8248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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