Article
Comparison of a rule-based algorithm with a phenotype-based algorithm for the interpretation of HIV genotypes in guiding salvage regimens in HIV-infected patients by a randomized clinical trial: the mutations and salvage study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 May 2006
Gianotti Nicola, Mondino Vincenzo, Rossi Maria Cristina, Chiesa Elisabetta, Mezzaroma Ivano, Ladisa Nicoletta, Guaraldi Giovanni, Torti Carlo, Tarquini Pierluigi, Castelli Paula, Di Carlo Aldo, Boeri Enzo, Keulen Wilco, Kenna Paula Mc, Lazzarin Adriano
Abstract excerpt
BACKGROUND: There is still considerable uncertainty as to the best algorithm for interpreting human immunodeficiency virus (HIV) genotyping results. METHODS: A total of 318 subjects with HIV RNA levels of >1000 copies/mL were enrolled in 41 centers throughout Italy from 2001 through 2003, stratified on the basis of their drug history, randomized (1:1) to 2 arms to have their treatments modified on the basis of...
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