Article
A randomized controlled trial to evaluate antiretroviral salvage therapy guided by rules-based or phenotype-driven HIV-1 genotypic drug-resistance interpretation with or without concentration-controlled intervention: the Resistance and Dosage Adapted Regimens (RADAR) study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jun 2005
Torti Carlo, Quiros-Roldan Eugenia, Regazzi Mario, De Luca Andrea, Mazzotta Francesco, Antinori Andrea, Ladisa Nicoletta, Micheli Valeria, Orani Anna, Patroni Andrea, Villani Paola, Lo Caputo Sergio, Moretti Francesca, Di Giambenedetto Simona, Castelnuovo Filippo, Maggi Paolo, Tinelli Carmine, Carosi Giampiero
Abstract excerpt
BACKGROUND: It is not well defined whether concentration-controlled intervention (CCI) and rules-based human immunodeficiency virus (HIV) type 1 genotype drug-resistance interpretation (GI) or virtual phenotype drug-resistance interpretation (VPI) may improve the outcome of HIV salvage therapy. METHODS: In a prospective, randomized, controlled trial, patients were randomized (on a factorial basis) to change...
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