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Article

Role of transmembrane segment 5 and extracellular loop 3 in the homodimerization of human ABCC1.

Biochemistry - 28 Dec 2010

Yang Youyun, Mo Wei, Zhang Jian-Ting

Abstract excerpt

Resistance to multiple anticancer agents is a major obstacle in the successful treatment of cancers. Overexpression of some ATP-binding cassette (ABC) membrane transporters such as ABCC1 has been shown to be a major contributor of multidrug resistance (MDR) in both laboratory cell line models and the clinical setting. ABCC1 has been thought to function as a homodimer with a putative dimerization domain located in...

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Source

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Identifiers

PMID: 21090806
DOI: 10.1021/bi101350x
PMCID: PMC3095655

Genes

ABCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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