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Article

Probing the conformation of hemoglobin presbyterian in the R-state.

Journal of protein chemistry - 1 Apr 2003

Acharya Seetharama A, Malavalli Ashok, Peterson Eric, Sun Philip D, Ho Chien, Prabhakaran Muthuchidambaram, Arnone Arthur, Manjula Belur N, Friedman Joel M

Abstract excerpt

The influence of allosteric effectors on the R-state (liganded) conformation of Tg-HbP (human hemoglobin Presbyterian expressed in transgenic pig) has been probed using a number of biophysical techniques, and the results have been compared with that of liganded of HbA (human normal adult hemoglobin) to gain insight into the molecular basis of Asn-108(beta)->Lys mutation-induced low-oxygen affinity of Hb. The...

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Identifiers

PMID: 12962322
DOI: 10.1023/a:1025080801951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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