Article
The Monod-Wyman-Changeux allosteric model accounts for the quaternary transition dynamics in wild type and a recombinant mutant human hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2012
Levantino Matteo, Spilotros Alessandro, Cammarata Marco, Schirò Giorgio, Ardiccioni Chiara, Vallone Beatrice, Brunori Maurizio, Cupane Antonio
Abstract excerpt
The acknowledged success of the Monod-Wyman-Changeux (MWC) allosteric model stems from its efficacy in accounting for the functional behavior of many complex proteins starting with hemoglobin (the paradigmatic case) and extending to channels and receptors. The kinetic aspects of the allosteric model, however, have been often neglected, with the exception of hemoglobin and a few other proteins where conformational...
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