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Article

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.

Cancer cell - 1 Apr 2006

Liu Yizhou, Cheney Matthew D, Gaudet Justin J, Chruszcz Maksymilian, Lukasik Stephen M, Sugiyama Daisuke, Lary Jeff, Cole James, Dauter Zbyszek, Minor Wladek, Speck Nancy A, Bushweller John H

Abstract excerpt

AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's...

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Topics

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Share to Binding Sites
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Hydrophobic and Hydrophilic Interactions

Share to Oncogene Proteins, Fusion

Share to Protein Structure, Quaternary

Share to RUNX1 Translocation Partner 1 Protein

Share to Sequence Alignment

Source

Identifiers

PMID: 16616331
DOI: 10.1016/j.ccr.2006.03.012

Genes

HDAC1
HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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