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Article

Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.

Journal of molecular biology - 24 Sept 2010

Corpora Takeshi, Roudaia Liya, Oo Zaw Min, Chen Wei, Manuylova Ekaterina, Cai Xiongwei, Chen Michael J, Cierpicki Tomasz, Speck Nancy A, Bushweller John H

Abstract excerpt

AML1-ETO is the chimeric protein product of t(8;21) in acute myeloid leukemia. The ETO portion of the fusion protein includes the nervy homology region (NHR) 3 domain, which shares homology with A-kinase anchoring proteins and interacts with the regulatory subunit of type II cAMP-dependent protei...

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Share to Bone Marrow Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Oncogene Proteins, Fusion

Share to Protein Structure, Tertiary

Share to Proto-Oncogene Proteins

Share to RUNX1 Translocation Partner 1 Protein

Source

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Identifiers

PMID: 20708017
DOI: 10.1016/j.jmb.2010.08.007
PMCID: PMC2945414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20708017-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.PMID 20708017Read ↗

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