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Article

Pleiotrophin induces transdifferentiation of monocytes into functional endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2006

Sharifi Behrooz G, Zeng Zhaohui, Wang Lai, Song Lei, Chen Haiming, Qin Minghui, Sierra-Honigmann M Rocio, Wachsmann-Hogiu Sebastian, Shah Prediman K

Abstract excerpt

OBJECTIVE: Pleiotrophin (PTN) is a cytokine that is expressed by monocytes/macrophages in ischemic tissues and that promotes neovascularization, presumably by stimulating proliferation of local endothelial cells. However, the effect of PTN on monocytes/macrophages remains unknown. We investigated the role of PTN in regulating the phenotype of monocytes/macrophages. METHODS AND RESULTS: RT-PCR, real-time PCR, and...

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Source

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Identifiers

PMID: 16614316
DOI: 10.1161/01.ATV.0000222017.05085.8e
PMCID: PMC3579570

Genes

PTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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