Article
Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.
Blood - 17 Mar 2011
Klimchenko Olena, Di Stefano Antonio, Geoerger Birgit, Hamidi Sofiane, Opolon Paule, Robert Thomas, Routhier Mélanie, El-Benna Jamel, Delezoide Anne-Lise, Boukour Siham, Lescure Bernadette, Solary Eric, Vainchenker William, Norol Françoise
Abstract excerpt
The early emergence of macrophages and their large pattern of tissue distribution during development suggest that they may play a critical role in the initial steps of embryogenesis. In the present study, we show that monocytic cells derived from human embryonic stem cells (hESCs) and from fetal liver follow a differentiation pathway different to that of adult cells, leading to specific functions. Embryonic and...
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