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Article

Tissue factor variants induce monocyte transformation and transdifferentiation into endothelial cell-like cells.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2017

Arderiu G, Espinosa S, Peña E, Crespo J, Aledo R, Bogdanov V Y, Badimon L

Abstract excerpt

Essentials Monocytes (Mo) transdifferentiate into endothelial cell-like (ECL) cells. Mo induce tissue factor (TF) expression and secretion in microvascular endothelial cells (mECs). TF interacts with Mo in a paracrine fashion, inducing their transdifferentiation into ECL cells. TF generates a positive feedback crosstalk between Mo and mECs that promotes angiogenesis. SUMMARY: Background Monocytes (Mo) increase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28585414
DOI: 10.1111/jth.13751

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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