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Article

Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.

Molecular and cellular biology - 1 May 2006

van der Weyden Louise, Arends Mark J, Chausiaux Oriane E, Ellis Peter J, Lange Ulrike C, Surani M Azim, Affara Nabeel, Murakami Yoshinori, Adams David J, Bradley Allan

Abstract excerpt

Tumor suppressor of lung cancer 1 (TSLC1), also known as SgIGSF, IGSF4, and SynCAM, is strongly expressed in spermatogenic cells undergoing the early and late phases of spermatogenesis (spermatogonia to zygotene spermatocytes and elongating spermatids to spermiation). Using embryonic stem cell technology to generate a null mutation of Tslc1 in mice, we found that Tslc1 null male mice were infertile. Tslc1 null...

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Identifiers

PMID: 16611999
DOI: 10.1128/MCB.26.9.3595-3609.2006
PMCID: PMC1447413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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