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Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice

20 May 2021

Abstract excerpt

Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa. Recently, a series of studies employing various in vivo and in vitro models have suggested a role of the wingless-related MMTV integration site gene family/beta-catenin (WNT/CTNNB1)...

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PMID: 34015032
DOI: 10.1371/journal.pone.0251911

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