The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

doi:10.1101/gad.9.9.1059

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Article

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

Genes & development - 1 May 1995

Ohkura H, Hagan I M, Glover D M

Abstract excerpt

We have identified a Schizosaccharomyces pombe gene with homology to the budding yeast gene CDC5, the Drosophila gene polo, and the mammalian family of genes encoding polo-like kinases. Disruption of this gene, plo1+, indicates that it is essential. Loss of plo1+ function leads to a mitotic arrest in which condensed chromosomes are associated with a monopolar spindle or to the failure of septation following the...

Topics

Actins
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Drosophila Proteins
Fungal Proteins
G1 Phase
G2 Phase
Gene Expression Regulation, Fungal
Genes, Fungal
Microtubules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Protein Serine-Threonine Kinases

Schizosaccharomyces

Sequence Analysis, DNA

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 7744248
DOI: 10.1101/gad.9.9.1059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7744248-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.PMID 7744248Read ↗

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