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Article

Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.

Neurobiology of disease - 1 Sept 2014

Chu Yaping, Goldman Jennifer G, Kelly Leo, He Yinzhen, Waliczek Tracy, Kordower Jeffrey H

Abstract excerpt

Both the misfolding of α-synuclein and mitochondrial dysfunction are considered two major contributors to Parkinson's disease (PD). However, the relationship between the two in normal and PD states remains unclear. Here, we report that voltage-dependent anion channel 1 (VDAC1), a major component of the outer mitochondrial membrane known to regulate mitochondrial functions, is down-regulated in response to...

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Source

Identifiers

PMID: 24825319
DOI: 10.1016/j.nbd.2014.05.003

Genes

VDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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