Article
[An evaluation for the function and significance concerned to alterations of P16 3D structure with gene mutation in esophageal squamous cell carcinoma].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Apr 2006
Chen Li-hong, Li Yi-wei, Gao Lin-yun, Liu Jin-feng
Abstract excerpt
OBJECTIVE: To investigate the clinicopathologic significance of P16 3D structure alterations in human esophageal squamous cell carcinoma(ESCC) so as to open a new approach for the research on clinical prevention and treatment of ESCC. METHODS: All three techniques of polymerase chain reaction-single strand comformation polymorphism (PCR-SSCP), DNA sequencing and computerized three-dimensional protein-modeling...
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