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Article

Catalytic properties of thimet oligopeptidase H600A mutant.

Biochemical and biophysical research communications - 2 Apr 2010

Machado Maurício F M, Marcondes Marcelo F, Rioli Vanessa, Ferro Emer S, Juliano Maria A, Juliano Luiz, Oliveira Vitor

Abstract excerpt

Thimet oligopeptidase (EC 3.4.24.15, TOP) is a metallo-oligopeptidase that participates in the intracellular metabolism of peptides. Predictions based on structurally analogous peptidases (Dcp and ACE-2) show that TOP can present a hinge-bend movement during substrate hydrolysis, what brings some residues closer to the substrate. One of these residues that in TOP crystallographic structure are far from the...

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Source

Identifiers

PMID: 20226173
DOI: 10.1016/j.bbrc.2010.03.045

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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