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Article

Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue.

Biochemical and biophysical research communications - 22 Jan 2022

Inukai Shunya, Hara Satoshi, Ichinose Hiroshi

Abstract excerpt

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine (DA), and the regulation of its activity is important for DA homeostasis. In this study, we focused on the modification of TH through a cysteine residue. We found that incubation with N-ethylmaleimide (NEM), a cysteine modification reagent, inactivated TH. The responsible cysteine was identified as Cys176 of human TH with...

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Identifiers

PMID: 34922205
DOI: 10.1016/j.bbrc.2021.12.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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