Article

A mitochondrial insertion directs substrate selection and engagement by ClpX

2026-02-23

Abstract excerpt

<h4>ABSTRACT</h4> The force-generating AAA+ ATPase domain of protein unfoldases is specified for many substrates and other functional partners through elaboration with accessory domains. Mitochondrial homologs of the unfoldase ClpX contain an insertion within the AAA+ domain that is absent in bacterial homologs. This mitochondrial insertion (MI) maps to the substrate-encountering face of ClpX, leading us to hypot...

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Literature Corpus work: 09f75347-6ad9-534e-b651-e2b6e98302ba
DOI: 10.64898/2026.02.23.707539

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