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Article

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.

Journal of virology - 1 Feb 2012

Won Sungyong, Eidenschenk Celine, Arnold Carrie N, Siggs Owen M, Sun Lei, Brandl Katharina, Mullen Tina-Marie, Nemerow Glen R, Moresco Eva Marie Y, Beutler Bruce

Abstract excerpt

The downregulation of translation through eIF2α phosphorylation is a cellular response to diverse stresses, including viral infection, and is mediated by the GCN2 kinase, protein kinase R (PKR), protein kinase-like endoplasmic reticulum kinase (PERK), and heme-regulated inhibitor kinase (HRI). Although PKR plays a major role in defense against viruses, other eIF2α kinases also may respond to viral infection and...

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Identifiers

PMID: 22114338
DOI: 10.1128/JVI.05660-11
PMCID: PMC3264364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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