Article

Characterization of Mice Bearing Humanized Androgen Receptor Genes (h/mAr) Varying in Polymorphism Length

2020-08-18

Abstract excerpt

The androgen receptor (AR) is known for masculinization of behavior and brain. To better understand the role that AR plays, mice bearing humanized Ar genes with varying lengths of a polymorphic N-terminal glutamine (Q) tract were created (Albertelli et al 2006). The length of the Q tract is inversely proporitional to AR activity. Biological studies of the Q tract length may also provide a window into potential AR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c29a9e61-7251-5097-9855-37a90b957a9e
DOI: 10.1101/2020.08.18.248153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of Mice Bearing Humanized Androgen Receptor Genes (h/mAr) Varying in Polymorphism LengthDOI 10.1101/2020.08.18.248153Read

Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice.Semantic proximity Read

Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice.Semantic proximity Read

Length of the human androgen receptor glutamine tract determines androgen sensitivity in vivo.Semantic proximity Read

Separate effects of sex hormones and sex chromosomes on brain structure and function revealed by high-resolution magnetic resonance imaging and spatial navigation assessment of the Four Core Genotype mouse model.Semantic proximity Read

Analysis of androgen receptor expression and activity in the mouse brainSemantic proximity Read

The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer.Semantic proximity Read

Gonadal and sex chromosomal contributions to sex differences in mammalian brain organizationSemantic proximity Read

Magel2 truncation alters select behavioral and physiological outcomes in a rat model of Schaaf-Yang syndrome.Semantic proximity Read

Altered brain structure in an ATRX-deficient mouse model of autism spectrum disorderSemantic proximity Read

Brain size reductions associated with endothelin B receptor mutation, a cause of Hirschsprung's disease.Semantic proximity Read

Genetic and morphological estimates of androgen exposure predict social deficits in multiple neurodevelopmental disorder cohortsSemantic proximity Read

Chromosomal and gonadal sex have differing effects on social motivation in miceSemantic proximity Read