Article
Pyrosequencing protocol requiring a unique biotinylated primer.
Clinical chemistry and laboratory medicine - 1 Jan 2006
Royo Jose Luis, Pascual Manuel Hidalgo, Salinas Ana, Tello Francisco Jose, Rivero Maria Del Carmen, Herrero Eduardo Ferrero, Real Luis Miguel, Ruiz Agustín
Abstract excerpt
BACKGROUND: DNA sequencing has markedly changed the nature of biomedical research. Large-scale sequencing projects have generated several millions of potential polymorphisms widespread in the human genome requiring validation and incorporation into screening panels. As a consequence, high-throughput analysis of these variants in different populations of interest is now the cornerstone of structural genomics....
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