Article
Priming of CD8+ T cell responses following immunization with heat‐killed Plasmodium sporozoites
6 Apr 2006
Abstract excerpt
Protective immune responses against malaria are induced by immunization with radiation-attenuated Plasmodium sporozoites. In contrast, non-viable, heat-killed sporozoites do not induce protection, emphasizing the requirement for live parasites to achieve effective immune responses. Using an experimental system with CD8+ T cells from T cell receptor-transgenic mice, we analyzed the primary CD8+ T cell responses...