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Article

Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites

2 Sept 2019

Abstract excerpt

Immunization with attenuated whole Plasmodium sporozoites constitutes a promising vaccination strategy. Compared to replication-deficient parasites, immunization with replication-competent parasites confers better protection and also induces a type I IFN (IFN-1) response, but whether this IFN-1 response has beneficial or adverse effects on vaccine-induced adaptive immunity is not known. Here, we show that IFN-1...

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PMID: 31477704
DOI: 10.1038/s41467-019-11819-0

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