Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive activity of muscarinic acetylcholine receptors.

Journal of receptor and signal transduction research - 1 Jan 2006

Spalding Tracy A, Burstein Ethan S

Abstract excerpt

We review the literature describing constitutive activity of the five muscarinic acetylcholine receptors in native and recombinant systems and discuss the effect of constitutive activity on muscarinic pharmacology in the context of modern models of receptor activation. We include a summary of mutations found to cause constitutive activity and discuss the implications of these data for the structure, function, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to GTP-Binding Proteins
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Receptors, Muscarinic

Source

Identifiers

PMID: 16595339
DOI: 10.1080/10799890600567349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive activity of muscarinic acetylcholine receptors.PMID 16595339Read ↗

Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6.Semantic proximity Read ↗

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.Semantic proximity Read ↗

Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor ActivitySemantic proximity Read ↗

Constitutive activity and inverse agonism at the alpha1adrenoceptors.Semantic proximity Read ↗

Constitutive activity of G-protein coupled receptors: emphasis on serotonin receptors.Semantic proximity Read ↗

Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Semantic proximity Read ↗

Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.Semantic proximity Read ↗

Characterization of constitutively active mutants of G protein-coupled receptors.Semantic proximity Read ↗

Lessons from constitutively active mutants of G protein-coupled receptors.Semantic proximity Read ↗

Constitutive activity and inverse agonism at the α(₁a) and α(₁b) adrenergic receptor subtypes.Semantic proximity Read ↗

Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening.Semantic proximity Read ↗

Homologous mutations near the junction of the sixth transmembrane domain and the third extracellular loop lead to constitutive activity and enhanced agonist affinity at all muscarinic receptor subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.