Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6.

Abstract excerpt

The m5 muscarinic acetylcholine receptor was constitutively activated by a wide range of amino acid substitutions at a residue (serine 465) that is positioned at the junction of the sixth transmembrane domain and the extracellular loop. Of 13 substitutions tested, 11 produced significant increases in constitutive activity. Replacement of serine 465 with large (phenylalanine and valine) or basic residues (arginine...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 3T3 Cells
• Share to Carbachol
• Share to Mice