Article
The HSV-1 latency associated transcript (LAT) variants 1704 and 1705 are glycoprotein C negative.
Virus research - 1 Jul 1991
Wroblewska Z, Spivack J G, Otte J, Steiner I, Brown M, MacLean A, Fraser N W
Abstract excerpt
The latency associated transcripts (LAT) of herpes simplex virus type 1 (HSV-1) are encoded by diploid genes that are expressed during latent infections. Two LAT variant viruses, 1704 and 1705, were compared with the parental strain 17+. Variant 1705 has a deletion affecting one copy of the LAT genes, expresses LATs during latent infection and reactivates normally. Variant 1704 has deletions affecting both LAT...
Topics
- Animals
- Chromosome Mapping
- Genes, Viral
- Genetic Variation
- Mice
- Mice, Inbred BALB C
- Mutation
- RNA, Viral
- Simplexvirus
- Transcription, Genetic
- Viral Envelope Proteins