Article
Identical 371-base-pair deletion mutations in the LAT genes of herpes simplex virus type 1 McKrae and 17syn+ result in different in vivo reactivation phenotypes.
Journal of virology - 1 Jan 1999
Loutsch J M, Perng G C, Hill J M, Zheng X, Marquart M E, Block T M, Ghiasi H, Nesburn A B, Wechsler S L
Abstract excerpt
The herpes simplex virus type 1 (HSV-1) LAT gene is the only viral gene abundantly transcribed during latency. LAT null mutants created with strains McKrae and 17syn+ are impaired for both in vivo spontaneous and in vivo-induced reactivation. Thus, LAT is essential for efficient in vivo-induced and spontaneous reactivation. Different investigators have studied two LAT mutants containing a StyI-StyI region...
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