Article
A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation.
Journal of virology - 1 Feb 1999
Perng G C, Slanina S M, Yukht A, Drolet B S, Keleher W, Ghiasi H, Nesburn A B, Wechsler S L
Abstract excerpt
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for efficient spontaneous reactivation of HSV-1 from latency. We previously reported that insertion of the LAT promoter and just the first 1.5 kb of the 8. 3-kb LAT gene into an ectopic location in the v...
Topics
- Animals
- Blotting, Southern
- Cell Line
- Cells, Cultured
- Chlorocebus aethiops
- Disease Models, Animal
- Female
- Herpes Simplex
- Herpesvirus 1, Human
- Humans
- Mutation
- Rabbits
- Transcription, Genetic
- Trigeminal Ganglion
- Virulence