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Article

Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.

European journal of preventive cardiology - 20 Sept 2024

Nordeidet Ada N, Klevjer Marie, Øvretveit Karsten, Madssen Erik, Wisløff Ulrik, Brumpton Ben M, Bye Anja

Abstract excerpt

AIMS: Resting heart rate (RHR) is associated with cardiovascular disease (CVD) and mortality. This study aimed to identify genetic loci associated with RHR, develop a genome-wide polygenic risk score (PRS) for RHR, and assess associations between the RHR PRS and CVD outcomes, to better understand the biological mechanisms linking RHR to disease. Sex-specific analyses were conducted to potentially elucidate...

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Identifiers

PMID: 38437179
DOI: 10.1093/eurjpc/zwae092
PMCID: PMC11412739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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