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Article

Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract.

Cancer research - 1 Apr 2006

Kucherlapati Melanie H, Nguyen Andrew A, Bronson Roderick T, Kucherlapati Raju S

Abstract excerpt

We have crossed mice carrying the conditional Rb(tm2Brn) allele with a constitutive Villin-Cre transgenic mouse. The Villin promoter in these animals is highly expressed in adult intestine and kidney proximal tubules and is expressed in the gut and nephros anlagen during embryogenesis. We report here that these mice develop tumors between 12 and 17 months old outside the gastrointestinal (GI) tract. A high...

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PMID: 16585182
DOI: 10.1158/0008-5472.CAN-05-2699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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