Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.

doi:10.1046/j.1471-4159.1995.64010213.x

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Article

Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.

Journal of neurochemistry - 1 Jan 1995

Carter L A, Belknap J K, Crabbe J C, Janowsky A

Abstract excerpt

The effects of ethanol, glycine, and spermidine on the specific binding of [3H]MK-801 were characterized in Triton-treated membranes prepared from the hippocampus and cortex of ethanol-withdrawal seizure-prone (WSP) and -resistant (WSR) mice. Glycine, an allosteric agonist at the NMDA receptor-linked ion channel complex, caused an increase in specific [3H]MK-801 binding to hippocampal membrane preparations. There...

Topics

Allosteric Regulation
Animals
Cerebral Cortex
Dizocilpine Maleate
Ethanol
Genetic Predisposition to Disease
Glycine
Hippocampus
Ion Channels
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

N-Methylaspartate

Receptors, N-Methyl-D-Aspartate

Seizures

Spermidine

Substance Withdrawal Syndrome

Source

Open in PubMed

Identifiers

PMID: 7528263
DOI: 10.1046/j.1471-4159.1995.64010213.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7528263-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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