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Article

Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.

Journal of neurochemistry - 1 Jan 1995

Carter L A, Belknap J K, Crabbe J C, Janowsky A

Abstract excerpt

The effects of ethanol, glycine, and spermidine on the specific binding of [3H]MK-801 were characterized in Triton-treated membranes prepared from the hippocampus and cortex of ethanol-withdrawal seizure-prone (WSP) and -resistant (WSR) mice. Glycine, an allosteric agonist at the NMDA receptor-linked ion channel complex, caused an increase in specific [3H]MK-801 binding to hippocampal membrane preparations. There...

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Source

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PMID: 7528263
DOI: 10.1046/j.1471-4159.1995.64010213.x

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