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Article

The ribonucleotide reductase domain of the R1 subunit of herpes simplex virus type 2 ribonucleotide reductase is essential for R1 antiapoptotic function.

The Journal of general virology - 1 Feb 2007

Chabaud Stéphane, Sasseville A Marie-Josée, Elahi Seyyed Mehdy, Caron Antoine, Dufour Florent, Massie Bernard, Langelier Yves

Abstract excerpt

The R1 subunit (ICP10) of herpes simplex virus type 2 (HSV-2) ribonucleotide reductase (RR), which in addition to its C-terminal reductase domain possesses a unique N-terminal domain of about 400 aa, protects cells against apoptosis. As the NH(2) domain on its own is not antiapoptotic, it has been postulated that both domains of R1 or part(s) of them could be necessary for this function. Here, N- and C-terminal...

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Identifiers

PMID: 17251554
DOI: 10.1099/vir.0.82383-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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