Article
Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo.
Antiviral research - 1 Feb 1992
Idowu A D, Fraser-Smith E B, Poffenberger K L, Herman R C
Abstract excerpt
The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions...
Topics
- Animals
- Female
- Ganglia, Spinal
- Guinea Pigs
- Herpes Genitalis
- Herpes Simplex
- Keratitis, Herpetic
- Male
- Mice
- Mutation
- Polymerase Chain Reaction
- Ribonucleotide Reductases
- Simplexvirus
- Trigeminal Ganglion
- Vagina
- Viral Plaque Assay
- Virulence