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Article

Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo.

Antiviral research - 1 Feb 1992

Idowu A D, Fraser-Smith E B, Poffenberger K L, Herman R C

Abstract excerpt

The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in mice following intracerebral, intraperitoneal, or intravaginal inoculation, or in guinea pigs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 1313220
DOI: 10.1016/0166-3542(92)90048-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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