Article
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Molecular and cellular biology - 1 Apr 2006
Lin Haijiang, Yamada Yasuhiro, Nguyen Suzanne, Linhart Heinz, Jackson-Grusby Laurie, Meissner Alexander, Meletis Konstantinos, Lo Grace, Jaenisch Rudolf
Abstract excerpt
Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we demonstrate that the loss of Dnmt3b has no impact on microadenoma formation, which is considered the earliest stage of intestinal tumor formation. Nevertheless, we...
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