gyrA mutations in ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus from Indiana, Minnesota, and Tennessee.

doi:10.1093/infdis/164.5.976

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Article

gyrA mutations in ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus from Indiana, Minnesota, and Tennessee.

The Journal of infectious diseases - 1 Nov 1991

Fasching C E, Tenover F C, Slama T G, Fisher L M, Sreedharan S, Oram M, Willard K, Sinn L M, Gerding D N, Peterson L R

Abstract excerpt

Mutational changes occurring at amino acid codons 84 and 85 located in the gyrA gene of methicillin-resistant Staphylococcus aureus (MRSA) were studied using radiolabeled oligonucleotide probes to examine the incidence of these ciprofloxacin resistance determinants in 30 MRSA isolates from Indiana, Minnesota, and Tennessee. Four separate oligonucleotide probes, one each corresponding to the wild-type sequence, a...

Topics

Base Sequence
Ciprofloxacin
Codon
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Humans
Indiana
Methicillin Resistance
Minnesota
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Hybridization

Oligonucleotide Probes

Restriction Mapping

Staphylococcus aureus

Tennessee

Source

Open in PubMed

Identifiers

PMID: 1658161
DOI: 10.1093/infdis/164.5.976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1658161-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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