Article
Screening of large numbers of Streptococcus pneumoniae isolates for mutations associated with fluoroquinolone resistance using an oligonucleotide probe assay.
FEMS microbiology letters - 17 Dec 2002
Davies Todd A, Goldschmidt Raul
Abstract excerpt
Mutations at a relatively small number of sites in parC, parE and gyrA account for most of the fluoroquinolone resistance in Streptococcus pneumoniae clinical isolates. A high throughput oligonucleotide probe assay was developed to screen for mutations in the quinolone-resistance determining regi...
Topics
- Anti-Infective Agents
- Base Sequence
- DNA Mutational Analysis
- Drug Resistance, Bacterial
- Fluoroquinolones
- Genes, Bacterial
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Streptococcus pneumoniae