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Article

Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese.

Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2006

Imamura Akiko, Okumura Kenji, Ogawa Yasuhiro, Murakami Ryuichiro, Torigoe Masayuki, Numaguchi Yasushi, Murohara Toyoaki

Abstract excerpt

BACKGROUND: The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes, including atherosclerosis. We tested the hypothesis that the G-395A polymorphism of the klotho gene is associated with increased risk for 2 types of ischemic heart disease in Japanese. METHODS: The study population consisted of 197 patients with coronary heart disease (CAD) who had >75%...

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Source

Identifiers

PMID: 16579981
DOI: 10.1016/j.cca.2006.02.021

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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