Article
Induction of the SOS response in Escherichia coli inhibits Tn5 and IS50 transposition.
Journal of bacteriology - 1 Nov 1991
Weinreich M D, Makris J C, Reznikoff W S
Abstract excerpt
In response to DNA damage or the inhibition of normal DNA replication in Escherichia coli, a set of some 20 unlinked operons is induced through the RecA-mediated cleavage of the LexA repressor. We examined the effect of this SOS response on the transposition of Tn5 and determined that the frequency of transposition is reduced 5- to 10-fold in cells that constitutively express SOS functions, e.g., lexA(Def)...
Topics
- Alleles
- Bacterial Proteins
- Base Sequence
- DNA Transposable Elements
- DNA, Bacterial
- Escherichia coli
- Kinetics
- Molecular Sequence Data
- Mutation
- Phenotype
- Rec A Recombinases
- SOS Response, Genetics
