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Article

Denaturing temperature selection may underestimate keratin mutation detection by DHPLC.

Human mutation - 1 May 2006

Strnad Pavel, Lienau Tim Christian, Tao Guo-Zhong, Ku Nam-On, Magin Thomas M, Omary M Bishr

Abstract excerpt

Keratins 8 and 18 (KRT8 and KRT18 genes; K8 and K18 proteins) variants are risk factors for developing end-stage liver disease and may be associated with inflammatory bowel disease and chronic pancreatitis. The frequency of K8/K18 variants in American, British, German, and Italian populations differs. For example, one study showed no amino acid-altering K8/K18 mutations in 256 German patients with liver...

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Share to Chromatography, High Pressure Liquid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16575832
DOI: 10.1002/humu.20311

Genes

KRT8
KRT18

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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