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Article

The rotenone model of Parkinson's disease: genes, environment and mitochondria.

Parkinsonism & related disorders - 1 Aug 2003

Greenamyre J Timothy, Betarbet Ranjita, Sherer Todd B

Abstract excerpt

Parkinson's disease (PD) is occasionally caused by single gene mutations or by single toxic exposures, but most cases of PD are probably caused by some combination of genetic susceptibility and environmental exposure. Using rotenone as a prototype for an environmental toxicant, we argue here that genetic and environmental causes of PD converge on common pathogenic mechanisms. If so, protective strategies devised...

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Identifiers

PMID: 12915069
DOI: 10.1016/s1353-8020(03)00023-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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