Article
Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification.
Medical science monitor : international medical journal of experimental and clinical research - 1 Apr 2006
Kardia Sharon L R, Bielak Lawrence F, Lange Leslie A, Cheverud James M, Boerwinkle Eric, Turner Stephen T, Sheedy Patrick F, Peyser Patricia A
Abstract excerpt
BACKGROUND: Coronary artery calcification (CAC) is an important indicator of future coronary artery disease events. Since elevated blood pressure (BP) is an important predictor of CAC, genetic polymorphisms in the renin-angiotensin system and their interaction may play a role in explaining CAC quantity variation. MATERIAL/METHODS: As part of the Epidemiology of Coronary Artery Calcification Study, 166...
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