Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.

doi:10.1016/0898-6568(91)90060-8

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Article

Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.

Cellular signalling - 1 Jan 1991

Rizzo M T, Boswell H S, English D, Gabig T G

Abstract excerpt

We previously showed that the proliferative response of a serum- and interleukin-3 (IL-3)-dependent murine myeloid cell line, NFS/N1-H7, was partially inhibited by pertussis toxin as a result of toxin-induced increased adenylate cyclase activity. In the present studies, we examined the role of the phosphoinositide cycle in the proliferative response of these cells and demonstrated that there was no change in PIP...

Topics

Adenylate Cyclase Toxin
Animals
Blood
Cell Division
Cell Line
Cell Membrane
Culture Media
Interleukin-3
Kinetics
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pertussis Toxin

Phosphatidylinositol 4,5-Diphosphate

Phosphatidylinositols

Proto-Oncogene Proteins p21(ras)

Thymidine

Type C Phospholipases

Virulence Factors, Bordetella

Source

Open in PubMed

Identifiers

PMID: 1657097
DOI: 10.1016/0898-6568(91)90060-8

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1657097-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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