Article
DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.
Development (Cambridge, England) - 1 Jan 2002
Jia Kailiang, Albert Patrice S, Riddle Donald L
Abstract excerpt
The daf-9 gene functions to integrate transforming growth factor-beta and insulin-like signaling pathways to regulate Caenorhabditis elegans larval development. Mutations in daf-9 result in transient dauer-like larval arrest, abnormal reproductive development, molting defects and increased adult longevity. The phenotype is sterol-dependent, and dependent on the activity of DAF-12, a nuclear hormone receptor....
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