Article
A nucleotide mutation associated with fluoroquinolone resistance observed in gyrA of in vitro obtained Rhodococcus equi mutants.
Veterinary microbiology - 15 Jun 2006
Niwa Hidekazu, Hobo Seiji, Anzai Toru
Abstract excerpt
In this study, the quinolone resistance-determining region (QRDR) in gyrA and gyrB of in vitro fluoroquinolone-resistant Rhodococcus equi mutants was sequenced. These mutants were selected from four R. equi strains on blood agar plates containing ciprofloxacin or enrofloxacin. Each mutant became 8- to 64 or greater-fold resistant to fluoroquinolones compared with their parent strains. From the results of sequence...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Gyrase
- Dose-Response Relationship, Drug
- Drug Resistance, Bacterial
- Fluoroquinolones
- Horses
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation