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Article

Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.

Antimicrobial agents and chemotherapy - 1 Apr 2017

Caspar Yvan, Siebert Claire, Sutera Vivien, Villers Corinne, Aubry Alexandra, Mayer Claudine, Maurin Max, Renesto Patricia

Abstract excerpt

Fluoroquinolone (FQ) resistance is a major health concern in the treatment of tularemia. Because DNA gyrase has been described as the main target of these compounds, our aim was to clarify the contributions of both GyrA and GyrB mutations found in Francisella novicida clones highly resistant to FQs. Wild-type and mutated GyrA and GyrB subunits were overexpressed so that the in vitro FQ sensitivity of functional...

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Identifiers

PMID: 28167561
DOI: 10.1128/AAC.02277-16
PMCID: PMC5365679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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