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Article

Site-Directed Mutagenesis of the Human Thyrotropin Receptor: Role of Asparagine-Linked Oligosaccharides in the Expression of a Functional Receptor

1 Jan 1991

Abstract excerpt

We studied the role of glycosylation in the expression of a functional human TSH receptor. Oligonucleotide-directed mutagenesis was used to replace, separately or together, the Asn codons with Gln in each of the six potential glycosylation sites in the receptor. Recombinant wild-type and mutated TSH receptors were stably expressed in Chinese hamster ovary cells. High affinity TSH binding and the cAMP response to...

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PMID: 2017190
DOI: 10.1210/mend-5-1-29

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Site-Directed Mutagenesis of the Human Thyrotropin Receptor: Role of Asparagine-Linked Oligosaccharides in the Expression of a Functional ReceptorPMID 2017190Read ↗

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