An insertion in the human thyrotropin receptor critical for high affinity hormone binding.

doi:10.1126/science.2169649

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Article

An insertion in the human thyrotropin receptor critical for high affinity hormone binding.

Science (New York, N.Y.) - 21 Sept 1990

Wadsworth H L, Chazenbalk G D, Nagayama Y, Russo D, Rapoport B

Abstract excerpt

Thyrotropin (TSH), luteinizing hormone (LH), and chorionic gonadotropin (CG) are structurally related glycoprotein hormones, which bind to receptors that share a high degree of sequence similarity. However, comparison of the primary amino acid sequences of the TSH and LH-CG receptors reveals two...

Topics

Animals
Base Sequence
Binding Sites
Cell Line
Chromosome Deletion
Clone Cells
Cyclic AMP
Humans
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Receptors, Thyrotropin
Thyrotropin
Transfection

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