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Article

Genetic backgrounds but not sizes of atherosclerotic lesions determine medial destruction in the aortic root of apolipoprotein E-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2003

Shi Weibin, Brown Morry D, Wang Xuping, Wong Jack, Kallmes David F, Matsumoto Alan H, Helm Gregory A, Drake Thomas A, Lusis Aldons J

Abstract excerpt

OBJECTIVE: Destruction of the elastic media is the most striking histologic feature of atherosclerotic aortic aneurysms. Apolipoprotein E-deficient (apoE-/-) mice fed a Western diet develop advanced atherosclerotic lesions in the aorta. We sought to assess the integrity of atherosclerotic aortic...

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Identifiers

PMID: 12920047
DOI: 10.1161/01.ATV.0000091249.34404.B7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12920047-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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