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Article

A role of matrix metalloproteinase-8 in atherosclerosis.

Circulation research - 23 Oct 2009

Laxton Ross C, Hu Yanhua, Duchene Johan, Zhang Feng, Zhang Zhongyi, Leung Kit-Yi, Xiao Qingzhong, Scotland Ramona S, Hodgkinson Conrad P, Smith Katherine, Willeit Johann, López-Otín Carlos, Simpson Iain A, Kiechl Stefan, Ahluwalia Amrita, Xu Qingbo, Ye Shu

Abstract excerpt

RATIONALE: Atherosclerotic lesions express matrix metalloproteinase (MMP)8, which possesses proteolytic activity on matrix proteins particularly fibrillar collagens and on nonmatrix proteins such as angiotensin (Ang) I. OBJECTIVE: We studied whether MMP8 plays a role in atherogenesis. METHODS AND RESULTS: In atherosclerosis-prone apolipoprotein E-deficient mice, inactivating MMP8 resulted in a substantial...

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Source

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Identifiers

PMID: 19745165
DOI: 10.1161/CIRCRESAHA.109.200279
PMCID: PMC2853782

Genes

MMP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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